Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension

AIMS: In pulmonary arterial hypertension (PAH), increases in endothelin-1 (ET-1) contribute to elevated pulmonary vascular resistance which ultimately causes death by right ventricular (RV) heart failure. ET antagonists are effective in treating PAH but lack efficacy in treating left ventricular (LV...

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Gepubliceerd in:Life Sci
Hoofdauteurs: Kuc, Rhoda E., Carlebur, Myrna, Maguire, Janet J., Yang, Peiran, Long, Lu, Toshner, Mark, Morrell, Nicholas W., Davenport, Anthony P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288792/
https://ncbi.nlm.nih.gov/pubmed/24582810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2014.02.020
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