The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Estetrol (E(4)) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E(2)) and E(4) are very similar, as well as their capacity to activate the two ac...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Abot, Anne, Fontaine, Coralie, Buscato, Mélissa, Solinhac, Romain, Flouriot, Gilles, Fabre, Aurélie, Drougard, Anne, Rajan, Shyamala, Laine, Muriel, Milon, Alain, Muller, Isabelle, Henrion, Daniel, Adlanmerini, Marine, Valéra, Marie-Cécile, Gompel, Anne, Gerard, Céline, Péqueux, Christel, Mestdagt, Mélanie, Raymond-Letron, Isabelle, Knauf, Claude, Ferriere, François, Valet, Philippe, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Lenfant, Françoise, Greene, Geoffrey L, Foidart, Jean-Michel, Arnal, Jean-François
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287935/
https://ncbi.nlm.nih.gov/pubmed/25214462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404112
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