Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). A fraction of ERα is targeted to plasma membrane and elicits membrane-initiated steroid signaling (MISS), but the physiological roles of MISS in vivo are poorly unde...

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Detalhes bibliográficos
Main Authors: Adlanmerini, Marine, Solinhac, Romain, Abot, Anne, Fabre, Aurélie, Raymond-Letron, Isabelle, Guihot, Anne-Laure, Boudou, Frédéric, Sautier, Lucile, Vessières, Emilie, Kim, Sung Hoon, Lière, Philippe, Fontaine, Coralie, Krust, Andrée, Chambon, Pierre, Katzenellenbogen, John A., Gourdy, Pierre, Shaul, Philip W., Henrion, Daniel, Arnal, Jean-François, Lenfant, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896153/
https://ncbi.nlm.nih.gov/pubmed/24371309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322057111
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