Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets

BACKGROUND: Human pancreatic islet structure poses challenges to investigations that require specific modulation of gene expression. Yet dissociation of islets into individual cells destroys cellular interactions important to islet physiology. Approaches that improve transient targeting of gene expr...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Tamaki, Stanley, Nye, Christopher, Slorach, Euan, Scharp, David, Blau, Helen M, Whiteley, Phyllis E, Pomerantz, Jason H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287515/
https://ncbi.nlm.nih.gov/pubmed/25305068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-86
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