Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

Cellular stresses activate the tumor suppressor p53 protein leading to selective binding to DNA response elements (REs) and gene transactivation from a large pool of potential p53 REs (p53REs). To elucidate how p53RE sequences and local chromatin context interact to affect p53 binding and gene trans...

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Publicat a:PLoS Genet
Autors principals: Su, Dan, Wang, Xuting, Campbell, Michelle R., Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Bell, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287438/
https://ncbi.nlm.nih.gov/pubmed/25569532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004885
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