Frequent co-amplification and co-operation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma

INTRODUCTION: Malignant pleural mesothelioma (MPM) is a deadly disease with poor prognosis and few treatment options. We characterized and elucidate the roles of C-MYC and PVT1 involved in the pathogenesis of MPM. METHODS: We used siRNA-mediated knockdown in MPM cell lines to determine the effect of...

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Pubblicato in:J Thorac Oncol
Autori principali: Riquelme, Erick, Suraokar, Milind B., Rodriguez, Jaime, Mino, Barbara, Lin, Heather Y., Rice, David C., Tsao, Anne, Wistuba, Ignacio I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287384/
https://ncbi.nlm.nih.gov/pubmed/24926545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000202
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