The Hypoxic Response Contributes to Altered Gene Expression and Pre-Capillary Pulmonary Hypertension in Patients with Sickle Cell Disease

BACKGROUND: We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS: To identify genes regulated by the hypoxic response and not other effects of chroni...

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Bibliografiska uppgifter
I publikationen:Circulation
Huvudupphovsmän: Zhang, Xu, Zhang, Wei, Ma, Shwu-Fan, Desai, Ankit A., Saraf, Santosh, Miasniakova, Galina, Sergueeva, Adelina, Ammosova, Tatiana, Xu, Min, Nekhai, Sergei, Abbasi, Taimur, Casanova, Nancy G., Steinberg, Martin H., Baldwin, Clinton T., Sebastiani, Paola, Prchal, Josef T., Kittles, Rick, Garcia, Joe G. N., Machado, Roberto F., Gordeuk, Victor R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287376/
https://ncbi.nlm.nih.gov/pubmed/24515990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.005296
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