Ablation of the Glucagon Receptor Gene Increases Fetal Lethality and Produces Alterations in Islet Development and Maturation

Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in the regulation of fetal growth and maturation is poorly understood. These issues were examined in a line of mice with a global deletion of the GLU receptor (Gcgr(−/−)), which are characterized by lower blood glucose lev...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Vuguin, Patricia M., Kedees, Mamdouh H., Cui, Lingguang, Guz, Yelena, Gelling, Richard W., Nejathaim, Morris, Charron, Maureen J., Teitelman, Gladys
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287247/
https://ncbi.nlm.nih.gov/pubmed/16627579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2005-1410
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