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Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages
Signal transduction from toll-like receptors (TLRs) is important for innate immunity against infections, but deregulated TLR signaling contributes to inflammatory disorders. Here we show that myeloid cell-specific ablation of TRAF2 greatly promotes TLR-stimulated proinflammatory cytokine expression...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4286812/ https://ncbi.nlm.nih.gov/pubmed/25565375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6930 |
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