Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/cyclin A complex using p27(KIP1)-derived peptidomimetic inhibitors

Functionally activated cyclin-dependent kinase 2 (CDK2)/cyclin A complex has been validated as an interesting therapeutic target to develop the efficient antineoplastic drug based on the cell cycle arrest. Cyclin A binds to CDK2 and activates the kinases as well as recruits the substrate and inhibit...

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Bibliographic Details
Published in:J Chem Biol
Main Authors: Karthiga, Arumugasamy, Tripathi, Sunil Kumar, Shanmugam, Ramasamy, Suryanarayanan, Venkatesan, Singh, Sanjeev Kumar
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286569/
https://ncbi.nlm.nih.gov/pubmed/25584078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-014-0124-y
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