A common functional consequence of tumor-derived mutations within c-MYC

The relevance of changes to the coding sequence of the c-MYC oncogene to malignancy is controversial. Overexpression of a pristine form of MYC is observed in many cancers and is sufficient to drive tumorigenesis in most contexts. Yet missense changes to MYC are found in ~50% of Burkitt’s lymphomas,...

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Publicado en:Oncogene
Autores principales: Chakraborty, Abhishek A., Scuoppo, Claudio, Dey, Soumyadeep, Thomas, Lance R., Lorey, Shelly L., Lowe, Scott W., Tansey, William. P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286529/
https://ncbi.nlm.nih.gov/pubmed/24998853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.186
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