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Two Pathways Mediate Inter-Domain Allosteric Regulation in Pin1
Allostery is an essential means for regulating biomolecular functions and provides unique opportunities for drug design, yet our ability to elucidate allosteric mechanisms remains limited. Here, based on extensive molecular dynamics simulations, we present an atomistic picture of the pathways mediat...
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| Publicado no: | Structure |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4286514/ https://ncbi.nlm.nih.gov/pubmed/25543254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.11.009 |
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