A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis

BACKGROUND: The combination of low-dose radiation therapy with poly (ADP-ribose) polymerase (PARP) inhibition has been shown to enhance anti-tumor efficacy through potentiating DNA damage. We combined low-dose fractionated whole abdominal radiation (LDFWAR) with escalating doses of veliparib (ABT-88...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Reiss, Kim A., Herman, Joseph M., Zahurak, Marianna, Brade, Anthony, Dawson, Laura A., Scardina, Angela, Joffe, Caitlin, Petito, Emily, Hacker-Prietz, Amy, Kinders, Robert J., Wang, Lihua, Chen, Alice, Temkin, Sarah, Horiba, Naomi, Siu, Lillian L., Azad, Nilofer S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286495/
https://ncbi.nlm.nih.gov/pubmed/25355929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1552
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