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Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy

To describe our 10-year experience in treating leptin-deficient humans. Three adults and one boy presented with childhood-onset morbid obesity, hypogonadism and family history of obesity and early death. Serum leptin was inappropriately low. A recessive C105T leptin gene mutation was identified. Met...

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Bibliografske podrobnosti
izdano v:Arq Bras Endocrinol Metabol
Main Authors: Paz-Filho, Gilberto, Mastronardi, Claudio, Delibasi, Tuncay, Wong, Ma-Li, Licinio, Julio
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286252/
https://ncbi.nlm.nih.gov/pubmed/21340154
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