Vitamin D Nuclear Receptor Deficiency Promotes Cholestatic Liver Injury by Disruption of Biliary Epithelial Cell Junctions in Mice

Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs. The aim of our study was thus to investigate the role...

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Détails bibliographiques
Publié dans:Hepatology
Auteurs principaux: Firrincieli, Delphine, Zúñiga, Silvia, Rey, Colette, Wendum, Dominique, Lasnier, Elisabeth, Rainteau, Dominique, Braescu, Thomas, Falguières, Thomas, Boissan, Mathieu, Cadoret, Axelle, Housset, Chantal, Chignard, Nicolas
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2013
Sujets:
Autoimmune, Cholestatic and Biliary Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286017/
https://ncbi.nlm.nih.gov/pubmed/23696511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26453
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