Overexpression of Insulin Receptor Substrate-2 in Human and Murine Hepatocellular Carcinoma

Deregulations in insulin and insulin-like growth factor (IGF) pathways may contribute to hepatocellular carcinoma. Although intracellular insulin receptor substrate-2 (IRS-2) is the main effector of insulin signaling in the liver, its role in hepatocarcinogenesis is unknown. Here, we show that IRS-2...

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Main Authors: Boissan, Mathieu, Beurel, Eléonore, Wendum, Dominique, Rey, Colette, Lécluse, Yann, Housset, Chantal, Lacombe, Marie-Lise, Desbois-Mouthon, Christèle
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2005
Teme:
Original Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698721/
https://ncbi.nlm.nih.gov/pubmed/16127164
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