Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated Ca(V)2.1 (P/Q-type) and Ca(V)3.2 (α(1H) T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties in cultured rat hippocampal neurons (Pe...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Perissinotti, Paula P., Ethington, Elizabeth A., Almazan, Erik, Martínez-Hernández, Elizabeth, Kalil, Jennifer, Koob, Michael D., Piedras-Rentería, Erika S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285801/
https://ncbi.nlm.nih.gov/pubmed/25610372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00444
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