Conformational activation of ADAMTS13

A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated proteolysis is determined by conformational changes in VWF, but also may depend on its own conformational activation. Kinetic analysi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: South, Kieron, Luken, Brenda M., Crawley, James T. B., Phillips, Rebecca, Thomas, Mari, Collins, Richard F., Deforche, Louis, Vanhoorelbeke, Karen, Lane, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284544/
https://ncbi.nlm.nih.gov/pubmed/25512499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411979112
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