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Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

Myosin binding protein-C (MyBP-C) is a key regulatory protein in heart muscle, and mutations in the MYBPC3 gene are frequently associated with cardiomyopathy. However, the mechanism of action of MyBP-C remains poorly understood, and both activating and inhibitory effects of MyBP-C on contractility h...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Kampourakis, Thomas, Yan, Ziqian, Gautel, Mathias, Sun, Yin-Biao, Irving, Malcolm
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284530/
https://ncbi.nlm.nih.gov/pubmed/25512492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413922112
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