Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.
In both transfected and normal hematopoietic cells, the majority of newly made erythropoietin receptor (EPO-R) subunits are retained in the endoplasmic reticulum (ER), destined for degradation. Only a small fraction exit the ER and are competent to bind EPO, suggesting that the EPO-R folds inefficie...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7816815/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.1.190 |
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