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Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.

In both transfected and normal hematopoietic cells, the majority of newly made erythropoietin receptor (EPO-R) subunits are retained in the endoplasmic reticulum (ER), destined for degradation. Only a small fraction exit the ER and are competent to bind EPO, suggesting that the EPO-R folds inefficie...

詳細記述

保存先:
書誌詳細
主要な著者: Hilton, D J, Watowich, S S, Murray, P J, Lodish, H F
フォーマット: Artigo
言語:Inglês
出版事項: 1995
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC42843/
https://ncbi.nlm.nih.gov/pubmed/7816815
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