Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents

A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular S(N)Ar reaction. All synthesized macrocyclic bisbibenzyls inhibite...

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Veröffentlicht in:Tetrahedron Lett
Hauptverfasser: Li, Rui-Juan, Zhao, Yu, Tokuda, Harukuni, Yang, Xiao-Ming, Wang, Yue-Hu, Shi, Qian, Morris-Natschke, Susan L., Lou, Hong-Xiang, Lee, Kuo-Hsiung
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283946/
https://ncbi.nlm.nih.gov/pubmed/25574060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2014.10.038
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