Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

Cancer genomes accumulate numerous genetic and epigenetic modifications. Yet, human cellular transformation can be accomplished by a few genetically defined elements. These elements activate key pathways required to support replicative immortality and anchorage independent growth, a predictor of tum...

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Bibliographic Details
Published in:EMBO J
Main Authors: Hong, Xin, Nguyen, Hung Thanh, Chen, Qingfeng, Zhang, Rui, Hagman, Zandra, Voorhoeve, P Mathijs, Cohen, Stephen M
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283404/
https://ncbi.nlm.nih.gov/pubmed/25180228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489385
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