Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

Cancer genomes accumulate numerous genetic and epigenetic modifications. Yet, human cellular transformation can be accomplished by a few genetically defined elements. These elements activate key pathways required to support replicative immortality and anchorage independent growth, a predictor of tum...

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Foilsithe in:EMBO J
Main Authors: Hong, Xin, Nguyen, Hung Thanh, Chen, Qingfeng, Zhang, Rui, Hagman, Zandra, Voorhoeve, P Mathijs, Cohen, Stephen M
Formáid: Artigo
Teanga:Inglês
Foilsithe: BlackWell Publishing Ltd 2014
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283404/
https://ncbi.nlm.nih.gov/pubmed/25180228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489385
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