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RESETing ER proteostasis: selective stress pathway hidden in the secretory route

The efficient folding of membrane and secreted proteins relies on the unfolded protein response (UPR) to buffer fluctuations in the load of misfolded proteins. Although the UPR is thought to operate on a generic manner to maintain ER proteostasis, a recent study revealed the existence of a novel mec...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Couve, Andrés, Hetz, Claudio
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283403/
https://ncbi.nlm.nih.gov/pubmed/25190517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489845
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