Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier

C9orf72 promoter hypermethylation inhibits the accumulation of pathologies which have been postulated to be neurotoxic. We tested here whether C9orf72 hypermethylation is associated with prolonged disease in C9orf72 mutation carriers. C9orf72 methylation was quantified from brain or blood using meth...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Russ, Jenny, Liu, Elaine Y., Wu, Kathryn, Neal, Donald, Suh, EunRan, Irwin, David J., McMillan, Corey T., Harms, Matthew B., Cairns, Nigel J., Wood, Elisabeth M., Xie, Sharon X., Elman, Lauren, McCluskey, Leo, Grossman, Murray, Van Deerlin, Vivianna M., Lee, Edward B.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282973/
https://ncbi.nlm.nih.gov/pubmed/25388784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1365-0
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