Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing (13)C(6)-glucose metabolic flux analysis, we show for the first time that...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Fack, Fred, Espedal, Heidi, Keunen, Olivier, Golebiewska, Anna, Obad, Nina, Harter, Patrick N., Mittelbronn, Michel, Bähr, Oliver, Weyerbrock, Astrid, Stuhr, Linda, Miletic, Hrvoje, Sakariassen, Per Ø., Stieber, Daniel, Rygh, Cecilie B., Lund-Johansen, Morten, Zheng, Liang, Gottlieb, Eyal, Niclou, Simone P., Bjerkvig, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282692/
https://ncbi.nlm.nih.gov/pubmed/25322816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1352-5
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