Peripheral natural killer cell maturation depends on the transcription factor Aiolos

Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initiated...

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Veröffentlicht in:EMBO J
Hauptverfasser: Holmes, Melissa L, Huntington, Nicholas D, Thong, Rebecca PL, Brady, Jason, Hayakawa, Yoshihiro, Andoniou, Christopher E, Fleming, Peter, Shi, Wei, Smyth, Gordon K, Degli-Esposti, Mariapia A, Belz, Gabrielle T, Kallies, Axel, Carotta, Sebastian, Smyth, Mark J, Nutt, Stephen L
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282578/
https://ncbi.nlm.nih.gov/pubmed/25319415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201487900
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