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APC/C(C)(dh1) controls CtIP stability during the cell cycle and in response to DNA damage

Human cells have evolved elaborate mechanisms for responding to DNA damage to maintain genome stability and prevent carcinogenesis. For instance, the cell cycle can be arrested at different stages to allow time for DNA repair. The APC/C(C)(dh1) ubiquitin ligase mainly regulates mitotic exit but is a...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Lafranchi, Lorenzo, de Boer, Harmen R, de Vries, Elisabeth GE, Ong, Shao-En, Sartori, Alessandro A, van Vugt, Marcel ATM
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282561/
https://ncbi.nlm.nih.gov/pubmed/25349192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489017
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