Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, and the autophagy-specific subunit ATG14. The structure of the ATG14-containing PI3KC3-C1 was determined...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Baskaran, Sulochanadevi, Carlson, Lars-Anders, Stjepanovic, Goran, Young, Lindsey N, Kim, Do Jin, Grob, Patricia, Stanley, Robin E, Nogales, Eva, Hurley, James H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281882/
https://ncbi.nlm.nih.gov/pubmed/25490155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05115
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