Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury

Aims: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme that participates in base-excision repair of oxidative DNA damage and in the redox activation of transcription factors. We tested the hypothesis that APE1 upregulation protects neuronal structure and function against trans...

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Veröffentlicht in:Antioxid Redox Signal
Hauptverfasser: Leak, Rehana K., Li, Peiying, Zhang, Feng, Sulaiman, Hassan H., Weng, Zhongfang, Wang, Guohua, Stetler, R. Anne, Shi, Yejie, Cao, Guodong, Gao, Yanqin, Chen, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
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Forum Original Research CommunicationsStroke (S. Cho and R. R. Ratan, Eds.)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281843/
https://ncbi.nlm.nih.gov/pubmed/24180454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5511
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