SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice

Glycoprotein VI and C-type lectin-like receptor 2 are essential platelet activating receptors in hemostasis and thrombo-inflammatory disease, which signal through a (hem)immunoreceptor tyrosine-based activation motif (ITAM)-dependent pathway. The adapter molecules Src-like adapter proteins (SLAP and...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Cherpokova, Deya, Bender, Markus, Morowski, Martina, Kraft, Peter, Schuhmann, Michael K., Akbar, Sarah M., Sultan, Cheryl S., Hughes, Craig E., Kleinschnitz, Christoph, Stoll, Guido, Dragone, Leonard L., Watson, Steve P., Tomlinson, Michael G., Nieswandt, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281827/
https://ncbi.nlm.nih.gov/pubmed/25301707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-580597
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