O-Fucose Monosaccharide of Drosophila Notch Has a Temperature-sensitive Function and Cooperates with O-Glucose Glycan in Notch Transport and Notch Signaling Activation

Notch (N) is a transmembrane receptor that mediates the cell-cell interactions necessary for many cell fate decisions. N has many epidermal growth factor-like repeats that are O-fucosylated by the protein O-fucosyltransferase 1 (O-Fut1), and the O-fut1 gene is essential for N signaling. However, the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ishio, Akira, Sasamura, Takeshi, Ayukawa, Tomonori, Kuroda, Junpei, Ishikawa, Hiroyuki O., Aoyama, Naoki, Matsumoto, Kenjiroo, Gushiken, Takuma, Okajima, Tetsuya, Yamakawa, Tomoko, Matsuno, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281752/
https://ncbi.nlm.nih.gov/pubmed/25378397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616847
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