Rescue of Notch signaling in cells incapable of GDP-l-fucose synthesis by gap junction transfer of GDP-l-fucose in Drosophila

Notch (N) is a transmembrane receptor that mediates cell–cell interactions to determine many cell-fate decisions. N contains EGF-like repeats, many of which have an O-fucose glycan modification that regulates N-ligand binding. This modification requires GDP-l-fucose as a donor of fucose. The GDP-l-f...

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Detalhes bibliográficos
Main Authors: Ayukawa, Tomonori, Matsumoto, Kenjiroo, Ishikawa, Hiroyuki O., Ishio, Akira, Yamakawa, Tomoko, Aoyama, Naoki, Suzuki, Takuya, Matsuno, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458340/
https://ncbi.nlm.nih.gov/pubmed/22949680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202369109
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