Evaluation of Anti-HIV-1 Mutagenic Nucleoside Analogues

Because of their high mutation rates, RNA viruses and retroviruses replicate close to the threshold of viability. Their existence as quasi-species has pioneered the concept of “lethal mutagenesis” that prompted us to synthesize pyrimidine nucleoside analogues with antiviral activity in cell culture...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Vivet-Boudou, Valérie, Isel, Catherine, El Safadi, Yazan, Smyth, Redmond P., Laumond, Géraldine, Moog, Christiane, Paillart, Jean-Christophe, Marquet, Roland
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281740/
https://ncbi.nlm.nih.gov/pubmed/25398876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616383
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