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Mg(2+) dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance
Metal ions are essential for DNA polymerase and RNase H activities of HIV-1 reverse transcriptase (RT). RT studies are routinely performed at 6–8 mM Mg(2+), despite the fact that the in vivo concentration might be as low as 0.2 mM. We studied the influence of MgCl(2) and ATP, which likely binds a si...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1325016/ https://ncbi.nlm.nih.gov/pubmed/16394022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj411 |
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