Activation of T-cell Protein-tyrosine Phosphatase Suppresses Keratinocyte Survival and Proliferation following UVB Irradiation

Chronic exposure to UV radiation can contribute to the development of skin cancer by promoting protein-tyrosine kinase (PTK) signaling. Studies show that exposure to UV radiation increases the ligand-independent activation of PTKs and induces protein-tyrosine phosphatase (PTP) inactivation. In the p...

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Udgivet i:J Biol Chem
Main Authors: Lee, Hyunseung, Morales, Liza D., Slaga, Thomas J., Kim, Dae Joon
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281716/
https://ncbi.nlm.nih.gov/pubmed/25406309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611681
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