11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue

Long-term glucocorticoid exposure increases the risk for developing type 2 diabetes. Prereceptor activation of glucocorticoid availability in target tissue by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) coupled with hexose-6-phosphate dehydrogenase (H6PDH) is an important mediator of the meta...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Wang, Ying, Yan, Chaoying, Liu, Limei, Wang, Wei, Du, Hanze, Fan, Winnie, Lutfy, Kabirullah, Jiang, Meisheng, Friedman, Theodore C., Liu, Yanjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281684/
https://ncbi.nlm.nih.gov/pubmed/25389364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00205.2014
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