Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice

The prereceptor activation of glucocorticoid production in adipose tissue by NADPH-dependent 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has emerged as a potential mechanism in the pathogenesis of visceral obesity and metabolic syndrome. Hexose-6-phosphate dehydrogenase (H6PDH) is an endoplas...

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Autors principals: Wang, Ying, Liu, Limei, Du, Hanze, Nagaoka, Yoshiko, Fan, Winnie, Lutfy, Kabirullah, Friedman, Theodore C., Jiang, Meisheng, Liu, Yanjun
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948972/
https://ncbi.nlm.nih.gov/pubmed/24381005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00491.2013
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