Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE(−/−) mice with partial carotid ligation

Disturbed blood flow (d-flow) occurring in branched and curved arteries promotes endothelial dysfunction and atherosclerosis, in part, by altering gene expression and epigenomic profiles in endothelial cells. While a systemic metabolic change is known to play a role in atherosclerosis, it is unclear...

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Detalhes bibliográficos
Publicado no:Am J Physiol Regul Integr Comp Physiol
Main Authors: Go, Young-Mi, Kim, Chan Woo, Walker, Douglas I., Kang, Dong Won, Kumar, Sandeep, Orr, Michael, Uppal, Karan, Quyyumi, Arshed A., Jo, Hanjoong, Jones, Dean P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Obesity, Diabetes and Energy Homeostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281678/
https://ncbi.nlm.nih.gov/pubmed/25377480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00278.2014
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