Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

Long-term exposure to peroxisome proliferator-activated receptor γ (PPARγ) agonists such as rosiglitazone induces browning of rodent and human adipocytes; however, the transcriptional mechanisms governing this phenotypic switch in adipocytes are largely unknown. Here we show that rosiglitazone-induc...

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Udgivet i:Genes Dev
Main Authors: Loft, Anne, Forss, Isabel, Siersbæk, Majken Storm, Schmidt, Søren Fisker, Larsen, Ann-Sofie Bøgh, Madsen, Jesper Grud Skat, Pisani, Didier F., Nielsen, Ronni, Aagaard, Mads Malik, Mathison, Angela, Neville, Matt J., Urrutia, Raul, Karpe, Fredrik, Amri, Ez-Zoubir, Mandrup, Susanne
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281566/
https://ncbi.nlm.nih.gov/pubmed/25504365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.250829.114
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