Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers

The proinflammatory cytokine tumor necrosis factor (TNF) plays a central role in low-grade adipose tissue inflammation and development of insulin resistance during obesity. In this context, nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) is directly involved and required for the ac...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Schmidt, Søren Fisker, Larsen, Bjørk Ditlev, Loft, Anne, Nielsen, Ronni, Madsen, Jesper Grud Skat, Mandrup, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561488/
https://ncbi.nlm.nih.gov/pubmed/26113076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.188300.114
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