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General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening

BACKGROUND: Pharmacological evidence suggests that inhalational general anesthetics induce neurodegeneration in vitro and in vivo through overactivation of inositol trisphosphate receptor (InsP(3)R) Ca(2+) release channels, but it is not clear whether these effects are due to direct modulation of ch...

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Vydáno v:Anesthesiology
Hlavní autoři: Joseph, J. Donald, Peng, Yi, Mak, Don-On Daniel, Cheung, King-Ho, Vais, Horia, Foskett, J. Kevin, Wei, Huafeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281525/
https://ncbi.nlm.nih.gov/pubmed/24878495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000316
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