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Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating: Kinetic Implications for the Durations of Calcium Puffs in Cells

The inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) is a ligand-gated intracellular Ca(2+) release channel that plays a central role in modulating cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)). The fungal metabolite adenophostin A (AdA) is a potent agonist of the InsP(3)R that is st...

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Bibliografske podrobnosti
Main Authors: Mak, Don-On Daniel, McBride, Sean, Foskett, J. Kevin
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217258/
https://ncbi.nlm.nih.gov/pubmed/11279251
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