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SINGLE-TUBE, HIGHLY PARALLEL MUTATION ENRICHMENT IN CANCER GENE PANELS USING TEMPERATURE-TOLERANT-COLD-PCR
BACKGROUND: Multiplexed detection of low-level mutations presents a technical challenge for many technologies, including cancer gene panels used for targeted-re-sequencing. Analysis of mutations below ~2–5% abundance in tumors with heterogeneity, samples with stromal contamination, or biofluids, is...
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| Publicado no: | Clin Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281501/ https://ncbi.nlm.nih.gov/pubmed/25297854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2014.228361 |
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