Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma

[Image: see text] EWS-FLI1 is an oncogenic fusion protein implicated in the development of Ewing’s sarcoma family tumors (ESFT). Using our previously reported lead compound 2 (YK-4-279), we designed and synthesized a focused library of analogues. The functional inhibition of the analogues was measur...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Tosso, Perrer N., Kong, Yali, Scher, Lauren, Cummins, Ryan, Schneider, Jeffrey, Rahim, Said, Holman, K. Travis, Toretsky, Jeffrey, Wang, Kan, Üren, Aykut, Brown, Milton L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281097/
https://ncbi.nlm.nih.gov/pubmed/25432018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501372p
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