Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti–HIV-1 drugs

During HIV-1 fusion to the host cell membrane, the N-terminal heptad repeat (NHR) and the C-terminal heptad repeat (CHR) of the envelope subunit gp41 become transiently exposed and accessible to fusion inhibitors or Abs. In this process, the NHR region adopts a trimeric coiled-coil conformation that...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Crespillo, Sara, Cámara-Artigas, Ana, Casares, Salvador, Morel, Bertrand, Cobos, Eva S., Mateo, Pedro L., Mouz, Nicolas, Martin, Christophe E., Roger, Marie G., El Habib, Raphaelle, Su, Bin, Moog, Christiane, Conejero-Lara, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280599/
https://ncbi.nlm.nih.gov/pubmed/25489108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413592112
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