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Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry
The search for therapeutic agents which bind specifically to precursor protein conformations and inhibit amyloid assembly is an important challenge. Identifying such inhibitors is difficult since many protein precursors of aggregation are partially folded or intrinsically disordered, ruling out stru...
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| Publicado en: | Nat Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280571/ https://ncbi.nlm.nih.gov/pubmed/25515893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2129 |
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