Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1(Osx)(−/−) mice

Neurofibromatosis type I (NF1) is an autosomal dominant disease with an incidence of 1/3000, caused by mutations in the NF1 gene, which encodes the RAS/GTPase-activating protein neurofibromin. Non-bone union following fracture (pseudarthrosis) in children with NF1 remains a challenging orthopedic co...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: de la Croix Ndong, Jean, Stevens, David M., Vignaux, Guillaume, Uppuganti, Sasidhar, Perrien, Daniel S., Yang, Xiangli, Nyman, Jeffry S., Harth, Eva, Elefteriou, Florent
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280331/
https://ncbi.nlm.nih.gov/pubmed/25043591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2316
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