Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1

Mineralization of the skeleton depends on the balance between levels of pyrophosphate (PPi), an inhibitor of hydroxyapatite formation, and phosphate generated from PPi breakdown by alkaline phosphatase (ALP). We report here that ablation of Nf1, encoding the RAS/GTPase–activating protein neurofibrom...

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Detalhes bibliográficos
Main Authors: de la Croix Ndong, Jean, Makowski, Alexander James, Uppuganti, Sasidhar, Vignaux, Guillaume, Ono, Koichiro, Perrien, Daniel S., Joubert, Simon, Baglio, Serena R., Granchi, Donatella, Stevenson, David A., Rios, Jonathan J., Nyman, Jeffry S., Elefteriou, Florent
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126855/
https://ncbi.nlm.nih.gov/pubmed/24997609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3583
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