Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1

Mineralization of the skeleton depends on the balance between levels of pyrophosphate (PPi), an inhibitor of hydroxyapatite formation, and phosphate generated from PPi breakdown by alkaline phosphatase (ALP). We report here that ablation of Nf1, encoding the RAS/GTPase–activating protein neurofibrom...

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Bibliografiska uppgifter
Huvudupphovsmän: de la Croix Ndong, Jean, Makowski, Alexander James, Uppuganti, Sasidhar, Vignaux, Guillaume, Ono, Koichiro, Perrien, Daniel S., Joubert, Simon, Baglio, Serena R., Granchi, Donatella, Stevenson, David A., Rios, Jonathan J., Nyman, Jeffry S., Elefteriou, Florent
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126855/
https://ncbi.nlm.nih.gov/pubmed/24997609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3583
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